![]() Guo YN, Li HR, Yang LS, Li YH, Wei BG, Wang WY et al (2017) Trace element levels in scalp hair of school children in Shigase, Tibet, an endemic area for Kashin-Beck disease(KBD). Wang KW, Yu J, Liu H, Liu YQ, Liu N, Cao Y, Zhang X, Sun D (2020) Endemic Kashin-Beck disease: a food-sourced osteoarthropathy. Zhang Y, He Y, Zhang D, Zhang M, Wang MY, Zhang Y, Ma T, Chen J (2018) Death of chondrocytes in Kashin-Beck disease: apoptosis, necrosis or necroptosis? Int J Exp Pathol 99:312–322. Zhang GQ, Liu JX, Yu JY, Shi YX, Zhang SJ (1989) Ultrastructure of chondrocytes in articular cartilage of Kashin-Beck disease. Song QQ, Liu H, Lian W, Wang Y, Sun LY, Gao M, Liu YQ, Deng HX, Deng Q, Liu N, Yu J (2018) The characteristics of positive and confusing hand X-ray signs in diagnosing Kashin-Beck disease in children in Chiina. Huang Q, Zhou ZK, Ma J, Li Y, Yang X, Shen B, Yang J, Kang PD, Pei FX (2015) The arthropathic and functional impairment features of adult Kashin-Beck disease patients in Aba Tibetan area in China. Guo X (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ (2014) Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. An analysis of research and public health activities based on a bibliography 1849-1992. HSP47 plays a role in the degenerative changes of KBD and associated with T-2 toxin-induced decreased type II collagen expression, further promoting matrix degradation.Īllander E (1994) Kashin-Beck disease. Se-supplementation partially antagonized the inhibitory effects of T-2 toxin in chondrocytes and cartilages. Hyaline-like cartilage with zonal layers was developed in engineered cartilaginous tissues, with decreased type II collagen and HSP47 expression found in T-2 toxin-treated group. Decreased type II collagen and HSP47 in C28/I2 and ATDC5 cells induced by T-2 toxin showed a dose-dependent manner. The low-Se + T-2 toxin animal group showed a significantly lower type II collagen expression along with decreased HSP47 expression. KBD cartilages showed increased chondronecrosis and extracellular matrix degradation in deep zone with decreased type II collagen and HSP47 expression. The distribution and expression of type II collagen and HSP47 were investigated through immunohistochemistry, western blotting, and real-time PCR. Cartilage degeneration was determined through histological evaluation. C28/I2 and ATDC5 cells and engineered tissue were exposed to different concentrations of T-2 toxin with or without Se. ATDC5 cells were seeded on bone matrix gelatin to construct engineered cartilaginous tissue. Rats were administered with T-2 toxin under the selenium (Se)-deficient diet. Hand phalange cartilages were collected from KBD and healthy children. ![]() We aimed to assess the abnormal expression of heat shock protein 47 (HSP47) which is associated with a decrease in type II collagen and an increase in cartilage degradation in KBD. Recent evidence suggests a role of type II collagen in Kashin-Beck disease (KBD) degeneration.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |